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. Author manuscript; available in PMC: 2019 Jun 18.
Published in final edited form as: Dev Cell. 2018 Jun 18;45(6):712–725.e6. doi: 10.1016/j.devcel.2018.05.026

Figure 6. Pharmacological Inhibition of Twist1 Suppresses Muscle Cachexia.

Figure 6

(A–E) KP53 or control mice were treated with JQ1 for 6 weeks (n= 10 or 12). Body weight (A), grip strength (B), GC muscle weight per BW (C), and GC muscle cross-sectional areas (D) were analyzed up to 6 weeks of treatment. Kaplan Meier survival was analyzed using 12 mice per group. p< 0.005 by log-rank test for significance (E). Scale bars: 25 μM.

(F and G) KP53Luc mice were treated with JQ1 for 3 or 6 weeks (n= 6). Tumor volumes in live mice were analyzed by IVIS bioluminescence (F). PDAC tumor weights were measured following 3 or 6 weeks of treatment (G).

Data in A, B, and C are expressed as mean ± SEM. *p < 0.05; **p < 0.01; ***p< 0.001; ns, not significant. See also Figure S6.