Figure 3. Hsp12 and trehalose can act synergistically in membrane proteostasis.

(A–B) Prion propagation as a measure of in vivo protein propagation after desiccation. (A) [PSI⁺] prion propagation before, and after desiccation. To assess [PSI⁺] prion state, cells were plated on media lacking adenine (SC-ADE) compared to non-dried controls. (B) [GAR⁺] prion propagation before, and after desiccation. To assess [GAR⁺] prion state, cells were plated on YP media with 2% glycerol and 0.05% glucosamine compared to non-dried controls.