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(A) AT9283 (pink) bound to the active site of Aurora A (PDB 2W1G, [Howard et al., 2009]) shows the DFGin-loop conformation and a salt bridge between K162 and E181. (B) Aurora A dimer (light and dark blue ribbon) in complex with AT9283 (pink) and inhibiting monobody (Mb, grey), showing DFGout-loop and broken K162 and E181 salt bridge (PDB 6CPG).
