Table 4.

Global changes of histone post-translational modifications during aging of the mammalian nervous system.

Mark	Change	Species	Tissues / Cell types	Age	Reference
H3K4me2	+	Macaque	Prefrontal cortex	0.4, 9, 22, 26Y	(Han et al., 2012)
H3K4me3	+	Human	Prefrontal cortex neurons	0.5 to 69Y	(Cheung et al., 2010)
	+	Human	Prefrontal cortex neurons	20–28Y vs 38–55Y	(Han et al., 2012)
	+	Mouse	Hippocampus	3–4M vs 18–20M	(Snigdha et al., 2016)
	=	Mouse	Cerebellum
	+	Rat	Hippocampus	3M vs 19–22M	(Morse et al., 2015)
H3K9ac	−	Mouse	Cochlea	8W vs 132W	(Watanabe and Bloch, 2013)
	=	Mouse	Hippocampus	3M vs 16M	(Peleg et al., 2010)
	+	Mouse	Cortical neurons	4–8W vs 55–65W	(Rodrigues et al., 2014)
H3K9me(all)	−	Rat	Hippocampus	3M vs 20M	(Elsner et al., 2013)
H3K9me2	+	Mouse	Cochlea	8W vs 132W	(Watanabe and Bloch, 2013)
H3K9me3	−	Mouse	Cortical neurons	4–8W vs 55–65W	(Rodrigues et al., 2014)
H3K14ac	=	Mouse	Hippocampus	3M vs 16M	(Peleg et al., 2010)
H3K20me2	−	Mouse	Brain	3M vs 22M	(Gong et al., 2015)
H3K27ac	=	Mouse	Brain	3M vs 22M	(Gong et al., 2015)
H3K27me3	−	Mouse	Brain	3M vs 22M	(Gong et al., 2015)
H3K56ac	=	Mouse	Brain	3M vs 22M	(Gong et al., 2015)
H3K79me3	−	Mouse	Brain	3M vs 22M	(Gong et al., 2015)
H3R2me2	−	Mouse	Brain	3M vs 22M	(Gong et al., 2015)
H4K5ac	=	Mouse	Hippocampus	3M vs 16M	(Peleg et al., 2010)
H4K8ac	=	Mouse	Hippocampus	3M vs 16M	(Peleg et al., 2010)
H4K12ac	=	Mouse	Hippocampus	3M vs 16M	(Peleg et al., 2010)
H4K16ac	=	Mouse	Hippocampus	3M vs 16M	(Peleg et al., 2010)
	=	Mouse	Brain	3M vs 22M	(Gong et al., 2015)
H4R3me2	=	Mouse	Brain	3M vs 22M	(Gong et al., 2015)

Data for retinal aging are not available. + and − represent higher and lower expression in aging, respectively. =, no change. Not all changes were normalized to the total levels of the respective histone. Ages are expressed in years (Y), months (M), or weeks (W).