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CRISPR-mediated genome surgery simplified schematic. Homology-directed repair (HDR) and non-homologous end joining (NHEJ). Cas9 endonuclease creates a double strand break (DSB) at the target location. DSB repair by HDR (left) utilizes a wild-type template strand resulting in DNA repair. DSB repair by NHEJ (right) introduces insertions and deletions (INDELs).
