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. 2018 Apr 3;11(3):664–671. doi: 10.1016/j.tranon.2018.02.023

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© 2018 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Tumor change ratio (%) versus treatment method: saline (n = 10), A30/G60 (n = 5), A20/G40 (n = 5), and A15/G30 (n = 12). Chemotherapy (gemcitabine plus Abraxane) leads to a significant decrease in tumor volume immediately after treatment in comparison to mice injected only with saline solution (P = .00008). During the whole treatment schedule (Q3D6) control tumors (saline injected mice) double in size on average. The highest dose of Abraxane (30 mg/kg) and gemcitabine (60 mg/kg) led to an average decrease of 61% in tumor volume immediately after treatment, while the lowest chemotherapy dose (Abraxane 15 mg/kg + gemcitabine 30 mg/kg) led to a 49% decrease in tumor volume (P = .12). This indicates the selected chemotherapy dosing is effective against PANC-1 tumors in Balb/c nude mice. The 50% difference in chemotherapy dosing led to a 12% change in tumor size. The therapy effectiveness was confirmed via histological analysis.