Table 3.

6 month infant neurodevelopmental outcomes by treatment group, assessed by the Ages and Stages Questionnaire

Outcome	Lifestyle advice (N = 1071)	Standard care (N = 1065)	Unadjusted treatment effect (95% CI)	Unadjusted P-value	Adjusted treatment effect (95% CI)	Adjusted P-value
Communication domain	51.30 (9.03)	50.95 (9.63)	0.35 (−0.68, 1.38)	0.501	0.36 (−0.67, 1.38)	0.493
Gross motor domain	53.35 (10.05)	52.74 (10.84)	0.61 (−0.54, 1.75)	0.297	0.55 (−0.59, 1.69)	0.344
Fine motor domain	52.25 (10.52)	51.20 (10.74)	1.05 (−0.11, 2.21)	0.075	1.00 (−0.13, 2.14)	0.082
Problem solving domain	53.60 (9.55)	52.86 (9.15)	0.74 (−0.29, 1.76)	0.158	0.72 (−0.31, 1.74)	0.170
Social domain	51.71 (9.52)	50.95 (9.74)	0.77 (−0.34, 1.87)	0.173	0.69 (−0.41, 1.79)	0.218
Total score	262.47 (34.92)	258.72 (36.54)	3.75 (−0.13, 7.63)	0.058	3.53 (−0.33, 7.40)	0.073
More than 1 score below cut-off*	49 (4.58)	69 (6.51)	0.70 (0.44, 1.12)	0.137	0.69 (0.43, 1.11)	0.126

Values are mean and standard deviation (or number and percentage), and treatment effects are differences in means (or relative risks) and are based on imputed data including all infants who were eligible for the follow-up study

Adjusted analyses included the stratification variables BMI category, parity and centre. Outcomes were additionally adjusted for maternal age, socioeconomic status and maternal smoking