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. 2018 Jul 20;8:10990. doi: 10.1038/s41598-018-29253-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Transduction of DARPin.9.26-functionalized lentiviral vector is HER2-expression-level-dependent. Naked or DARPin-functionalized Sind-PDZ1-pp was used to transduce target cells with different levels of surface HER2 receptor (the estimated number of HER2 receptor per cell is shown in parenthesis²⁴). Similar transduction efficiency was observed for VSV-Gpp in all cell types regardless of their cell surface HER2 levels.