Fig. 2.

MLI host and microbiota proteome landscape alterations in pediatric IBD. a PCA score plot of MLI human-derived proteins quantified in ≥50% of the samples; b PCA score plot of MLI microbiome-derived proteins quantified in ≥ 50% of the samples; c, d Group mean clustering based on Mahalanobis distances calculated with MANOVA test using the first 10 PCs of PCA on MLI human-derives proteins (c) and MLI microbiome-derives proteins (d). The clusters are computed by applying the single linkage method to the matrix of Mahalanobis distances between group means. ***p < 0.001