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. 2018 Jul 20;8:10984. doi: 10.1038/s41598-018-28862-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Heatmap of similarity for metadata generated by HAllA. (a) No variables had similarities scores >0.5 with the SLA-cluster. Other variables that are associated (case status, Stage of NEC and Surgery) are as expected, as each relates to the disease status; Birthweight, gestational age (GA) at birth, and day of life (DOL) sample was obtained created a cluster as they were fixed for during control selection. All other associations are from temporally stratified feeding and medication information. (b) Within cases alone no given variable tested associated with the SLA-cluster. Similarity scores for metadata are visualized in a heatmap generated with corrplots in R. Size and color of circles represent similarity score values.