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. 2018 Jul 20;8:10978. doi: 10.1038/s41598-018-29379-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparing a prototype tomographic scanner dedicated to histopathology (Tomopath) with a commercial tabletop micro-CT scanner. (A) Cross-sectional image at 1.3 mm level below the surface of a paraffin block from the Tomopath scanner. Left-anterior-descending (LAD) coronary artery segments of a deceased HIV patient are embedded in the block. The vessel walls appear bright against a dark background from the x-ray absorption contrast between tissue and paraffin medium. The grid-like shadows are cast by the plastic grid of the embedding cassette. (B) Cross-sectional image at the same level from the commercial tabletop micro-CT scanner. (C) Zoomed-in view of the top left LAD segment outlined in A from the Tomopath scanner. The layers of the vessel wall are visible. The scan times of the micro-CT and the Tomopath scanners were 2.75 hours and 15 minutes, respectively. (D) Picture of the intact paraffin block prior to histological sectioning.