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. 2018 Jul 20;8:10973. doi: 10.1038/s41598-018-29384-9

Table 1.

Proteins quantified by iTRAQ-MARS. Identification and quantification of proteins were performed using the Protein Pilot Paragon Method.

Accessiona Namea Gene Namea B115:P114b A116:P114b C117:P114b
1 RM10_HUMAN 39 S ribosomal protein L10, mitochondrial MRPL10 1.08 1.03 0.66
2 APCL_HUMAN Adenomatous polyposis coli protein 2 APC2 3.67 6.62 4.88
3 SIA7E_HUMAN Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 ST6GALNAC5 1.42 2.14 1.74
4 RNPL1_HUMAN Arginyl aminopeptidase-like 1 RNPEPL1 0.21 0.68 0.75
5 ANPRB_HUMAN Atrial natriuretic peptide receptor 2 NPR2 1.38 3.67 2.76
6 CTF8A_HUMAN Chromosome transmission fidelity protein 8 homolog isoform 2 CHTF8 2.44 4.11 3.30
7 CC183_HUMAN Coiled-coil domain-containing protein 183 (Isoform 4) CCDC183 2.35 2.05 1.43
8 CC186_HUMAN Coiled-coil domain-containing protein 186 CCDC186 1.55 3.86 1.94
9 CO5A1_HUMAN Collagen alpha-1(V) chain COL5A1 1.98 3.36 2.92
10 CR2_HUMAN Complement receptor type 2 (Isoform D) CR2 1.81 3.22 2.47
11 NEUL1_HUMAN E3 ubiquitin-proteinligase NEURL1 NEURL1 1.49 3.96 2.57
12 FLNC_HUMAN Filamin-C FLNC 1.23 3.94 3.93
13 GRASP_HUMAN General receptor for phosphoinositides 1-associated scaffold protein (isoforms 2) GRASP 1.24 2.56 2.20
14 GLHA_HUMAN Glycoprotein hormones alpha chain CGA 1.52 1.71 1.72
15 GCC2_HUMAN GRIP and coiled-coil domain-containing protein 2 GCC2 1.61 4.83 3.08
16 H3C_HUMAN Histone H3.3C H3F3C 2.06 4.63 3.39
17 HV311_HUMAN Ig heavy chain V-III region KOL IGHV3–33 1.37 2.52 0.81
18 IPO8_HUMAN Importin-8 IPO8 1.36 1.60 1.73
19 G137C_HUMAN Integral membrane protein GPR137C GPR137C 2.00 4.20 2.60
20 ITIH1_HUMAN Inter-alpha-trypsin inhibitor heavy chain H1 ITIH1 2.02 1.34 1.31
21 DCP2_HUMAN m7GpppN-mRNA hydrolase DCP2 1.10 3.52 2.50
22 MPEG1_HUMAN Macrophage-expressed gene 1 protein MPEG1 2.33 6.14 2.93
23 KISS1_HUMAN Metastasis-suppressor KiSS-1 KISS1 3.38 2.63 1.64
24 MIIP_HUMAN Migration and invasion-inhibitory protein MIIP 2.36 4.22 3.47
25 MINT_HUMAN Msx2-interacting protein SPEN 1.73 3.85 4.55
26 MUC16_HUMAN Mucin-16 MUC16 2.40 5.37 4.02
27 MUC19_HUMAN Mucin-19 MUC19 1.87 4.26 2.44
28 MCTP1_HUMAN Multiple C2 and transmembrane domain-containing protein 1 MCTP1 3.11 7.33 2.57
29 ACM1_HUMAN Muscarinic acetylcholine receptor M1 CHRM1 1.00 2.49 1.43
30 NDUA5_HUMAN NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 (Isoform2) NDUFA5 1.09 2.85 3.08
31 PK3CG_HUMAN Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 2.36 2.39 1.86
32 PMF1_HUMAN Polyamine-modulated factor 1 (Isoform 2) PMF1 1.40 0.00 0.86
33 PSME2_HUMAN Proteasome activator complex subunit 2 PSME2 1.50 5.20 1.24
34 K1456_HUMAN Putative methyltransferase KIAA1456 KIAA1456 1.57 2.94 1.97
35 SHSA8_HUMAN Putative protein shisa-8 SHISA8 2.24 4.32 2.90
36 RANB9_HUMAN Ran-binding protein 9 (Isoform 2) RANBP9 2.28 2.35 2.82
37 RALB_HUMAN Ras-related protein Ral-B RALB 0.26 1.28 0.07
38 EWS_HUMAN RNA-binding protein EWS EWSR1 1.03 1.89 1.06
39 SPCS3_HUMAN Signal peptidase complex subunit 3 SPCS3 1.33 3.49 2.63
40 SLF2_HUMAN SMC5-SMC6 complex localization factor protein 2 SLF2 1.29 0.78 2.63
41 SPEG_HUMAN Striated muscle preferentially expressed protein kinase SPEG 1.30 3.85 1.41
42 TPC12_HUMAN Traffickingproteinparticlecomplexsubunit 12 TRAPPC12 0.81 2.30 0.99
43 TRIM3_HUMAN Tripartite motif-containing protein 3 (Isoform Gamma) TRIM3 3.14 6.92 4.49
44 UBP37_HUMAN Ubiquitin carboxyl-terminal hydrolase 37 USP37 1.54 2.48 1.58
45 CX023_HUMAN Uncharacterized protein CXorf23 CXorf23 1.90 3.49 2.91
46 WDR97_HUMAN WD repeat-containing protein KIAA1875 WDR97 2.78 2.42 3.45
47 XKR7_HUMAN XK-related protein 7 XKR7 0.95 2.47 2.07
48 ZC11A_HUMAN Zinc finger CCCH domain-containing protein 11A ZC3H11A 2.17 4.67 2.06
49 ZN592_HUMAN Zinc finger protein 592 ZNF592 2.96 6.72 6.03

The MS/MS data were processed using a mass tolerance of 10 ppm and 0.2 Da for the precursor and fragment ions, respectively. aAccording to “UniProtKB” (http://www.uniprot.org/). bThe relative quantification was calculated according to Protein Pilot, and based on the ratio of the reporter ions corresponding to the A116, B115 and C117 tryptic peptides, over the ratio of the P114 reporter ions. Proteins giving tryptic peptides with an average reporter ion ratio ≥2 or ≤0.5 were classified as up- or down-regulated, respectively.