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. 2018 Jul 20;9:2868. doi: 10.1038/s41467-018-05029-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Methylation signature of pineoblastoma, pineal gland, and PPTID. Pediatric pineoblastomas form a distinct cluster that is separated from normal pineal gland and pineal parenchymal tumor of intermediate differentiation (PPTID). However, adult pineoblastomas cluster with PPTID (PB3 and PB8) as well as the normal pineal gland group (PB23), although analyzed tissues were confirmed as pineoblastoma, suggesting that methylation signature reflects origin of adult pineoblastomas from a normal pineal gland or a lower grade precursor lesion