Fig. 2.

Genomic landscape of pineoblastoma. Whole-exome sequencing was performed in 13 tumors with no matching germline (exome samples, left). Whole-genome sequencing (genome samples, right) was performed in five tumors, two primary (PB1 and PB12) with matched peripheral blood DNA and three metastasis from PB1 (M1, M2, M3). Specific genes are shown that bear nonsynonymous mutations. In exome samples only mutations enriched in pathway analysis via Ingenuity Pathway Analysis (IPA) software are included. In genome samples, only somatic nonsynonymous mutations are presented. Sufficient material was available to confirm mutations in eight tumors (mutations validated). See also Supplementary Table 1 for mutation details