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. 2018 Jul 20;9:2868. doi: 10.1038/s41467-018-05029-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — PDE4DIP microduplication correlates with overexpression of DUF1220. Pineoblastomas with PDE4DIP microduplication (n = 7) show strong expression of both PDE4DIP protein (a), as well as DF1220 protein (f), while pineoblastomas with no PDE4DIP microduplication (n = 5) (b, g) and normal pineal gland (c, h) are negative for both proteins. DUF1220 is strongly expressed in the germinal matrix of the fetal brain (i), consistent with its established role in human brain development; however, fetal brain neuroblasts are completely negative for PDE4DIP expression (d). Adult brain tissue is negative for both PDE4DIP and DUF1220 protein expression (e, j). (n = 5 for each normal control group, original magnification 400×, Scale bar 100 µm)