Table 1.
Peptide No. | CPP | Amino acid sequence | Number of amino acids | CPP typea | Net charge at pH7 | Reference |
---|---|---|---|---|---|---|
1 | BP100 | KKLFKKILKYL | 11 | A | 5 | 20 |
2 | 2BP100 | KKLFKKILKYLKKLFKKILKYL | 22 | C | 10 | 17 |
3 | Rev(34–50) | TRQARRNRRRRWRERQR | 17 | C | 9 | 47 |
4 | R9 | RRRRRRRRR | 9 | C | 9 | 48 |
5 | D-R9 | rrrrrrrrr (D form) | 9 | C | 9 | 49 |
6 | R12 | RRRRRRRRRRRR | 12 | C | 12 | this study |
7 | KH9 | KHKHKHKHKHKHKHKHKH | 18 | C | 9.9 | 50 |
8 | K9 | KKKKKKKKK | 9 | C | 9 | this study |
9 | K18 | KKKKKKKKKKKKKKKKKK | 18 | C | 18 | this study |
10 | Pen2W2F | RQIKIFFQNRRMKFKK | 16 | C | 7 | 51 |
11 | DPV3 | RKKRRRESRKKRRRES | 16 | C | 10 | 52 |
12 | 6-Oct | GRKRKKRT | 8 | C | 6 | 53 |
13 | R9-TAT | GRRRRRRRRRPPQ | 13 | C | 9 | 47 |
14 | Tat(49–57) | RKKRRQRRR | 9 | C | 8 | 49 |
15 | Retro - Tat(57–49) | RRRQRRKKR | 9 | C | 8 | 49 |
16 | Sc18 | GLRKRLRKFRNKIKEK | 16 | A | 8 | 54 |
17 | KLA10 | KALKKLLAKWLAAAKALL | 18 | A | 5 | 55 |
18 | IX | QLALQLALQALQAALQLA | 18 | H | 0 | 55 |
19 | XI | LKTLATALTKLAKTLTTL | 18 | H | 3 | 55 |
20 | No. 14–12 | RAWMRWYSPTTRRYG | 15 | A | 4 | 56 |
21 | pVEC | LLIILRRRIRKQAHAHSK | 18 | A | 6.2 | 57 |
22 | PenArg | RQIRIWFQNRRMRWRR | 16 | A | 7 | 51 |
23 | M918 | MVTVLFRRLRIRRACGPPRVRV | 22 | A | 6.9 | 58 |
24 | Penetratin | RQIKIWFQNRRMKWKK | 16 | A | 7 | 59 |
25 | PolyP 3 (SAP) | VRLPPPVRLPPPVRLPPP | 18 | H | 3 | 60 |
26 | dhvar5 | LLLFLLKKRKKRKY | 14 | A | 7 | 61 |
27 | HPV33L2-445/467 | SYFILRRRRKRFPYFFTDVRVAA | 23 | A | 6 | 62 |
28 | buforin II (5–21) | RAGLQFPVGRVHRLLRK | 17 | A | 5.1 | 63 |
29 | scrambled pVEC | IAARIKLRSRQHIKLRHL | 18 | A | 6.2 | 64 |
30 | HPV33L2-DD447 | SYDDLRRRRKRFPYFFTDVRVAA | 23 | A | 4 | 62 |
31 | LAH4 | KKALLALALHHLAHLALHLALALKKA | 26 | H | 4.4 | 65 |
32 | ppTG1 | GLFKALLKLLKSLWKLLLKA | 20 | A | 5 | 66 |
33 | Transportan (TP) | GWTLNSAGYLLGKINLKALAALAKKIL | 27 | H | 4 | 67 |
34 | 2 × ppTG1 | GLFKALLKLLKSLWKLLLKAGLFKALLKLLKSLWKLLLKA | 40 | A | 10 | 15 |
35 | pAntpHD(Pro50) | RQIKIWFPNRRMKWKK | 16 | A | 7 | 68 |
36 | pAntp(44–58) | QIKIWFQNRRMKWKK | 15 | A | 6 | 69 |
37 | Crot(27–39) | KMDCRWRWKCCKK | 13 | A | 4.8 | 70 |
38 | Crot(27–39) derevative (1) | MDCRWRWKCCKK | 12 | A | 3.8 | 70 |
39 | Crot(27–39) derevative (2) | KCGCRWRWKCGCKK | 14 | A | 5.7 | 70 |
40 | CyLoP-1 | CRWRWKCCKK | 10 | A | 4.8 | 70 |
41 | Inv3 | TKRRITPKDVIDVRSVTTEINT | 22 | H | 2 | 71 |
42 | Inv5 | AEKVDPVKLNLTLSAAAEALTGLGDK | 26 | H | -1 | 72 |
43 | Inv3.5 | TKRRITPKDVIDVRSVTTKINT | 22 | H | 4 | 72 |
44 | Inv3.10 | HHHHHHTKRRITPKDVIDVRSVTTEINT | 28 | H | 2.6 | 72 |
45 | ARF(1–22) | MVRRFLVTLRIRRACGPPRVRV | 22 | A | 6.9 | 73 |
46 | Cyt C 77–101 | GTKMIFVGIKKKEERADLIAYLKKA | 25 | A | 4 | 74 |
47 | hLF peptide | KCFQWQRNMRKVRGPPVSCIKR | 22 | A | 6.9 | 48 |
48 | Glu-Oct-6 | EEEAAGRKRKKRT | 13 | A | 3 | 75 |
49 | M511 | FLGKKFKKYFLQLLK | 15 | A | 5 | 76 |
50 | G53-4 | FLIFIRVICIVIAKLKANLMCKT | 23 | H | 3.9 | 76 |
51 | M591 | YIVLRRRRKRVNTKRS | 16 | A | 8 | 76 |
52 | E162 | KTVLLRKLLKLLVRKI | 16 | A | 6 | 76 |
53 | E165 | LLKKRKVVRLIKFLLK | 16 | A | 7 | 76 |
54 | M867 | KKICTRKPRFMSAWAQ | 16 | A | 4.9 | 76 |
55 | MG2d | GIGKFLHSAKKWGKAFVGQIMNC | 23 | H | 4 | 77 |
aC: cationic, A: amphipathic, H: hydrophobic.