Table 3. Modulation of canonical pathways (CPs) in HCT116 and HepG2 by MP-HX.
The table shows the top canonical pathways modulated by MP-HX in the cell lines. They were ranked by IPA software based on −log (p-value).
| Canonical pathway | −log (p-value) | |
|---|---|---|
| HCT116 | HepG2 | |
| 1. Cell Cycle Control of Chromosomal Replication | 20.34 | 5.67 |
| 2. Role of BRCA1 in DNA Damage Response | 8.36 | 6.28 |
| 3. Hereditary Breast Cancer Signaling | 5.95 | 7.25 |
| 4. ATM Signaling | 6.08 | 6.19 |
| 5. Cell Cycle: G2/M DNA Damage Checkpoint Regulation | 6.96 | 4.66 |
| 6. Estrogen-mediated S-phase Entry | 6.25 | 5.29 |
| 7. Mitotic Roles of Polo-Like Kinase | 6.91 | 3.54 |
| 8. Unfolded protein response | 6.35 | 3.55 |
| 9. NRF2-mediated Oxidative Stress Response | 2.96 | 6.61 |
| 10. Mismatch Repair in Eukaryotes | 5.84 | 3.68 |