. Author manuscript; available in PMC: 2019 Aug 1.

Published in final edited form as: Int J Parasitol. 2018 Jun 6;48(9-10):773–783. doi: 10.1016/j.ijpara.2018.04.002

Table 1.

Titer of antigen-specific IgG antibodies in the sera of rBmHAXT or rBmHAT vaccinated macaques. Macaques were immunized (s/c) with four doses (150 μg each dose) of respective protein (rBmHAXT/rBmHAT) in AL007 (alum adjuvant) or Al019 (alum plus glucopyranosyl lipid adjuvant-stable emulsion) as adjuvant on days 0, 28, 56 and 84. Blood samples were collected prior to each immunization and the levels of antigen-specific total IgG antibodies were analyzed in all the groups of immunized animals. The variables are mean of each group. n=10 macaques per group.

Macaque groups (n=10)	Immunizations
Macaque groups (n=10)	First	Second	Third	Fourth
rBmHAT+AL007	1:1250	1:20,000	1:20,000	1:20,000
rBmHAT+AL019	1:10,000	1:20,000	1:20,000	1:20,000
rBmHAXT+AL019	1:1250	1:20,000	1:20,000	1:20,000
AL019	1:125	1:125	1:125	1:125

rBmHAT, recombinant Brugia malayi HSP12.6+ALT-2+TSPLEL); rBmHAXT, recombinant B. malayi HSP12.6+ALT-2+TPX+TSPLEL.