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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Exp Eye Res. 2018 Apr 17;173:32–43. doi: 10.1016/j.exer.2018.04.010

Figure 3. Nmnat1E257K/− mice exhibit photoreceptor dysfunction.

Figure 3

Electroretinogram recordings performed on Nmnat1E257K/− mutant mice and Nmnat1E257K/+ or Nmnat1+/− littermate control mice at 1 month, 5 months, and 12 months of age averaged from n ≥ 5 per group per genotype. (A) A significant reduction in the a-wave amplitude was detected in 5-month-old and 12-month-old Nmnat1E257K/− mutant mice (shown in red) compared to the a-wave amplitude of age-matched control littermates (shown in blue). (B) ERG responses (n≥ 5) of the b-wave show no marked decrease in amplitude in Nmnat1E257K/− mutant mice compared to Nmnat1E257K/+ or Nmnat1+/− littermate control mice at 1 month, 5 months, and 12 months of age.