Skip to main content
. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Exp Eye Res. 2018 Apr 17;173:32–43. doi: 10.1016/j.exer.2018.04.010

Figure 5. Light induced damage triggers rapid degeneration of photoreceptors of Nmnat1E257K/− mutant mice.

Figure 5

(A, B) Scotopic and photopic ERG were recorded to evaluate the before and after effects of light damage (LD) on Nmnat1E257K/− mutant mice compared to control age-matched littermates (n ≥ 5 per genotype). (C, D) H&E staining and retinal morphometry show marked photoreceptor degeneration in 10 weeks-old mutant mice after light exposure at 8 weeks of age compared to controls. RPE= retinal pigment epithelium, ONL= outer nuclear layer, INL= inner nuclear layer, OPL= outer plexiform layer, IPL= inner plexiform layer, GCL= ganglion cell layer, OS= outer segment, IS= inner segment.