Table 2.

Univariate and multivariate Cox regression models for progression-free survival (N = 98)

		Univariate Cox regression model		Multivariate Cox regression model (ODS1 pos vs neg)		Multivariate Cox regression model (ODS2 pos vs neg)
		HR (95% CI)	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value
ODS1	Pos vs Neg	2.42 (1.44–4.06)	0.001	2.16 (1.28–3.64)	0.004
ODS2	Pos vs Neg	2.76 (1.59–4.80)	<0.001			2.61 (1.49–4.58)	0.001
Gender	Female vs Male	0.79 (0.51–1.24)	0.315
ECOG PS	1–2 vs 0	1.25 (0.82–1.89)	0.293
Side	DX + TV vs SX	0.93 (0.61–1.41)	0.730
Targeted Agents in first-line therapy	Yes vs No	0.86 (0.57–1.31)	0.498
Surgery for metastatic disease	Yes vs No	0.63 (0.40–1.01)	0.054	0.58 (0.36–0.93)	0.024	0.56 (0.35–0.89)	0.015
Number of metastatic sites	2–3 vs 1	1.75 (1.14–2.68)	0.010	1.73 (1.11–2.70)	0.016	1.81 (1.16–2.82)	0.009

The multivariate Cox models were built with variables testing significant in univariate analysis