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. 2018 Jul 16;9:720. doi: 10.3389/fphar.2018.00720

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Copyright © 2018 Prabhu, Siveen, Kuttikrishnan, Iskandarani, Khan, Merhi, Omri, Dermime, El-Elimat, Oberlies, Alali and Uddin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of GC on cell proliferation and cell cycle. (A) Chemical structure of GC. (B) Inhibition of cell viability was measured using MTT assay as described under the section “Materials and Methods.” Cell cycle fraction analysis of cells in response to GC. K562 (C) and U937 (D) cells were treated with GC as indicated and analyzed by flow cytometry. GC significantly enhanced SubG0 fraction in K562 (E) and U937 (F). The graph displays the mean ±SD of three independent of experiments. ^∗P < 0.05.