Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jul 16;6:99. doi: 10.3389/fbioe.2018.00099

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Weber, Steinle, Golombek, Hann, Schlensak, Wendel and Avci-Adali.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Schematic representation of major reactions in blood induced by biomaterial surface. Besides complement system, intrinsic and extrinsic coagulation pathway can be activated. Coagulation activation results in generation of a fibrin network. Furthermore, platelets can adhere and aggregate on the surface. The adhesion and activation of leukocytes can lead to the release of polymorphonuclear (PMN) elastase and tissue factor (TF) and result in activation of extrinsic pathway. ADP, Adenosine diphosphate; β-TG, β-Thromboglobulin; GPIIb/IIIa, Glycoprotein IIb/IIIa; MAC, Membrane attack complex; PF4, Platelet factor 4; TXA2, Thromboxane A2; vWF, von Willebrand factor.