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miRNA therapeutics investigated in animal models of colorectal cancer
| miRNA | Animal model | Restoring or suppressing miRNA function | Therapeutic outcome | Ref. |
| miR-34a | Transgenic mice | Restoring | Anti-tumor | [126] |
| miR-135b | Xenotranplantation of tumor-derived organoids to mice | Suppression (antisense) | Anti-tumor | [129] |
| miR-143 | Mice xenograft | Restoring | Anti-tumor | [132] |
| miR-145 | Mice xenograft | Restoring | Negative effect | [132] |
| miR-4689 | Mice xenograft | Restoring (mimic) | Anti-tumor | [135] |
