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. 2018 Jul 16;9:1624. doi: 10.3389/fimmu.2018.01624

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Copyright © 2018 Sun, Luo, Zhao, Huang, Qin, Su and Yan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Top enrichment KEGG pathway. (A) Bubble graph of top enrichment KEGG pathway. Red bubbles are remarkable pathway (adj p-value <0.05); yellow bubble is the pathway which has the most number of differentially expressed genes; green bubbles are other pathways. (B) Simplified overview of sigX-RNAi strain interacting with the host intestinal immune network for IgA pathway. (C) Simplified overview of sigX-RNAi strain interacting with the host coagulation and complement system. (D) Simplified overview of sigX-RNAi strain interacting with the host chemokine signaling pathway. The black letter genes in (B–D) represent no different expression and the red letter genes in (B–D) are up-regulated in spleen infected by sigX-RNAi strain compared with the counterpart infected by wild-type strain.