Figure 2.

Linear depiction of overlapping reading frames of the Polymerase (P) and Surface (S) genes, highlighting five “mirror mutations” (4) where a nucleotide substitution influences amino acids in both S and P proteins. Gene lengths are given in nucleotides (black central bar); protein numbering based on the HBVdb X02763 amino acid sequence (7) is shown in color (Polymerase in red, Surface in green) for the whole protein. Mutations are given in amino acid positions in the affected gene segment, with the mutations in bold indicating the primary mutation with functional effect, and those in regular text indicating the secondary mirror mutation with any incidental functional effect.