Table 4.

Lethal doses 50% (LD₅₀) and 90% (LD₉₀) in G. mellonella larvae for the indicated K. pneumoniae strains^a.

Strainb	Genotypec	Colistin MICd	LD50	LD90	R2
6	ST45/F	64	5.98 × 102	2.21 × 103	0.988
2	ST629/D	16	8.56 × 103	3.51 × 104	0.964
3	ST101/B	256	1.98 × 104	4.84 × 105	0.807
8	ST512/A4	256	6.51 × 104	4.83 × 106	0.768
4	ST258/A2	8	7.18 × 104	1.71 × 106	0.659
10	ST258/A2	4	7.46 × 104	2.58 × 106	0.740
11	ST512/A	128	9.45 × 104	2.21 × 106	0.825
20	ST449/E	16	9.93 × 104	3.43 × 106	0.832
17	ST512/A3	128	1.02 × 105	3.57 × 106	0.822
19	ST512/A	256	1.35 × 105	2.82 × 106	0.749
26	ST1685/B2	0.125	2.29 × 105	4.99 × 106	0.702
7	ST101/B1	32	4.46 × 105	6.03 × 106	0.790
9	ST392/C	32	7.24 × 105	8.27 × 106	0.824
5	ST629/D	256	7.86 × 105	6.42 × 106	0.997
27	ST512/A5	0.125	8.46 × 105	5.32 × 106	0.970
1	ST258/A2	8	8.80 × 105	6.58 × 106	0.933
13	ST258/A1	64	1.01 × 106	7.58 × 106	0.940
21	ST512/A	256	2.91 × 106	4.24 × 107	0.893

^aLD₅₀, LD₉₀, and R²-values were determined using the GraphPad Prism software and the dose-dependent survival curves shown in the Figure S3. LD₅₀ and LD₉₀ are expressed as number of viable cells.

^bStrains have been ordered according to increasing LD₅₀ values.

^cST and PFGE profiles are shown.

^dColistin MICs are expressed as mg/L.