Table 3.

Responder rates to ketogenic diet according to the identified pathogenic gene, with the P value for the comparison with the responder rate of patients without identified genetic mutations.

Pathogenic gene (n = 73)	At 3 months		At 6 months		At 12 months
	Responders	p	Responders	p	Responders	p
ARX (1)	1/1 (100.0%)	0.337	1/1 (100.0%)	0.301	1/1 (100.0%)	0.301
CACNA1A (1)	1/1 (100.0%)	0.337	0/1 (0.0%)	1.000	0/1 (0.0%)	1.000
CDKL5 (10)	0/10 (0.0%)	0.031	0/10 (0.0%)	0.058	0/10 (10.0%)	0.058
CHD2 (3)	1/3 (33.3%)	1.000	0/3 (0.0%)	0.555	0/3 (0.0%)	0.555
CLCN4 (1)	0/1 (0.0%)	1.000	0/1 (0.0%)	1.000	0/1 (0.0%)	1.000
COL4A1 (2)	1/2 (50.0%)	1.000	1/2 (50.0%)	0.509	1/2 (50.0%)	0.509
EEF1A2 (2)	0/2 (0.0%)	1.000	0/2 (0.0%)	1.000	0/2 (0.0%)	1.000
GNAO1 (1)	0/1 (0.0%)	1.000	0/1 (0.0%)	1.000	0/1 (0.0%)	1.000
IQSEC2 (1)	0/1 (0.0%)	1.000	0/1 (0.0%)	1.000	0/1 (0.0%)	1.000
KANSL1 (1)	1/1 (100.0%)	0.337	1/1 (100.0%)	0.301	1/1 (100.0%)	0.301
KCNA1 (1)	0/1 (0.0%)	1.000	0/1 (0.0%)	1.000	0/1 (0.0%)	1.000
KCNB1 (2)	2/2 (100.0%)	0.116	2/2 (100.0%)	0.093	2/2 (100.0%)	0.093
KCNQ2 (6)	5/6 (83.3%)	0.022	5/6 (83.3%)	0.014	5/6 (83.3%)	0.014
KCNT1 (3)	0/3 (0.0%)	0.548	0/3 (0.0%)	0.555	0/3 (33.3%)	0.555
MECP2 (3)	0/3 (0.0%)	0.548	0/3 (0.0%)	0.555	0/3 (0.0%)	0.555
SCN1A (18)	14/18 (77.8%)	0.001	14/18 (77.8%)	<0.001	11/18 (61.1%)	0.014
SCN2A (3)	3/3 (100%)	0.041	3/3 (100.0%)	0.030	3/3 (100.0%)	0.030
SCN3A (1)	1/1 (100.0%)	0.337	1/1 (100.0%)	0.301	1/1 (100.0%)	0.301
SCN8A (3)	0/3 (0.0%)	0.548	0/3 (0.0%)	0.555	0/3 (0.0%)	0.555
SLC6A1 (1)	1/1 (100.0%)	0.337	1/1 (100.0%)	0.301	1/1 (100.0%)	0.301
SLC9A6 (2)	1/2 (50.0%)	1.000	1/2 (50.0%)	0.509	1/2 (50.0%)	0.509
STXBP1 (4)	4/4 (100%)	0.015	4/4 (100%)	0.010	4/4 (100.0%)	0.010
SYNGAP (1)	0/1 (0.0%)	1.000	0/1 (0.0%)	1.000	0/1 (0.0%)	1.000
WWOX (1)	1/1 (100.0%)	0.337	1/1 (100.0%)	0.301	1/1 (100.0%)	0.301
ZEB2 (1)	1/1 (100.0%)	0.337	1/1 (100.0%)	0.301	0/1 (0.0%)	1.000