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. 2018 Jul 16;9:773. doi: 10.3389/fphar.2018.00773

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Copyright © 2018 Youn, Park, Kim, Jung, Kang, Lim, Song, Kwak and Um.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of BBR on histological changes and protein expression of PSA in prostate tissues of TP-induced BPH rats. (A) Representative photomicrographs of H&E stained prostate tissues (left panels, magnification ×200; right panels, magnification ×400) are shown. (B) The epithelial thickness and (C) the relative lumen area of the prostate tissues were measured using ImageJ software. Values are mean ± SD of of ten or more separate measurements. (D) The protein expression of PSA was analyzed by a Western blot analysis. Values are mean ± SD of three or more separate measurements. ^#P < 0.05 when compared to NC; ^∗P < 0.05 when compared to BPH. The protein expression differences are normalized to GAPDH. NC, normal control group; BPH, TP-induced BPH group; BBR, BBR-treated BPH group; Fi, finasteride-treated BPH group.