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. 2018 Jul 16;9:773. doi: 10.3389/fphar.2018.00773

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Copyright © 2018 Youn, Park, Kim, Jung, Kang, Lim, Song, Kwak and Um.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of BBR on expressions of 5AR, AR and its coactivator SRC1 in prostate tissues of TP-induced BPH rats. (A) Representative photomicrographs of IHC stained prostate tissues with anti-AR, anti-5AR, and anti-SRC1 antibodies (magnification ×400) are shown. (B) The protein expressions of 5AR, AR, and SRC1 were analyzed by a Western blot analysis. Values are mean ± SD of three or more separate measurements. ^#P < 0.05 when compared to NC; ^∗P < 0.05 when compared to BPH. The protein expression differences are normalized to GAPDH. NC, normal control group; BPH, TP-induced BPH group; BBR, BBR-treated BPH group; Fi, finasteride-treated BPH group.