Table 1.
Group characteristics.
| rrMS | spMS | Healthy controls | ||||
|---|---|---|---|---|---|---|
| Male: 7, female: 38 | Male: 6, female: 29 | Male: 10, female: 31 | ||||
| DMT: 34 (76%) | DMT: 11 (31%) | |||||
| Mean | SD | Mean | SD | Mean | SD | |
| Age (years) a,c | 44.0 | 10.9 | 52.1 | 10.6 | 41.8 | 16.2 |
| Time since diagnosis (months) a | 111.0 | 84.8 | 228.7 | 103.5 | ||
| EDSS a | 3.4 | 2.0 | 5.8 | 1.5 | ||
| Cognitive fatigue score (FSMC) b,c | 31.8 | 9.9 | 33.8 | 9.7 | 18.2 | 7.8 |
| Motor fatigue score (FSMC) a,b,c | 34.1 | 9.2 | 38.3 | 6.1 | 18.5 | 7.5 |
| Total fatigue score (FSMC)b, c | 65.9 | 17.2 | 72.1 | 14.5 | 36.7 | 14.8 |
| Fatigue severity scale scoreb, c | 42.0 | 15.6 | 41.8 | 15.9 | 24.4 | 11.3 |
| Psychological item score (BDI)c | 5.2 | 4.1 | 6.5 | 5.2 | 3.6 | 4.2 |
| IL-1beta (pg/ml)c | 242.9 | 126.6 | 294.1 | 168.1 | 222.7 | 138.0 |
a
significant difference (p < 0.05) between rrMS and spMS.
b
significant difference (p < 0.05) between rrMS and healthy controls.
c
significant difference (p < 0.05) between spMS and healthy controls.
BDI, beck depression inventory; DMT, disease modifying therapy; EDSS, expanded disability status scale; FSMC, fatigue scale for motor and cognition; rrMS, relapsing remitting multiple sclerosis; SD, standard deviation; spMS, secondary progressive multiple sclerosis.