Table 1.
Characteristics of the included articles.
| Study, year | Study design | Country/region | Ethnicity | Variant | Cases/controls |
|---|---|---|---|---|---|
| Geraldine Cancel-Tassin, 2015 (Cancel-Tassin et al., 2015) | Population-based case–control study | France | African | rs16901979 | 489/534 |
| Mian Li, 2011 (Li et al., 2011) | Case–control study | China | Asian | rs16901979 | 432/782 |
| Maurice P Zeegers, 2011 (Zeegers et al., 2011) | Cohort Study | Netherlands | Caucasian | rs1447295 | 281/267 |
| Marcelo Chen, 2010 (Chen et al., 2010) | Case–control study | China | Asian | rs16901979 | 331/335 |
| rs6983561 | 324/336 | ||||
| Prodipto Pal, 2009 (Pal et al., 2009) | Case–control study | USA | Caucasian | rs16901979 | 596/567 |
| rs1447295 | |||||
| rs6983267 | |||||
| rs4645959 | |||||
| rs1016343 | |||||
| Marcelo Chen, 2009 (Chen et al., 2009) | Hospital-based case–control study | China | Asian | rs1447295 | 340/337 |
| Andreas Meyer, 2009 (Meyer et al., 2009) | Hospital-based case–control study | Germany | Caucasian | rs1447295 | 486/462 |
| rs13281615 | 488/462 | ||||
| Iona Cheng, 2008 (Cheng et al., 2008) | Case–control study | USA | Caucasian | rs16901979 | 417/416 |
| African | 89/87 | ||||
| rs1447295 | 417/417 | ||||
| 89/89 | |||||
| DG8S737 | 416/417 | ||||
| 89/89 | |||||
| rs6983561 | 417/417 | ||||
| 88/89 | |||||
| rs10090154 | 417/414 | ||||
| 89/88 | |||||
| rs7000448 | 416/417 | ||||
| 89/89 | |||||
| rs6983267 | 417/417 | ||||
| 89/89 | |||||
| rs13254738 | 506/506 | ||||
| 89/88 | |||||
| Christiane Robbins, 2007 (Robbins et al., 2007) | Case–control study | USA | African | rs16901979 | 490/567 |
| rs1447295 | |||||
| DG8S737 | |||||
| rs6983267 | |||||
| rs7008482 | |||||
| Miia Suuriniemi, 2007 (Suuriniemi et al., 2007) | Population-based case–control study | USA | Caucasian | rs1447295 | 582/538 |
| Fredrick R. Schumacher, 2007 (Schumacher et al., 2007) | Nested case-control study | Multiple countries | Caucasian | rs1447295 | 5505/6270 |
| African | 676/643 | ||||
| Julius Gudmundsson, 2007 (Gudmundsson et al., 2007) | Case–control study | Iceland | Caucasian | rs16901979 | 2663/5509 |
| African | 373/372 | ||||
| Caucasian | rs1447295 | ||||
| African | |||||
| Gianluca Severi, 2007 (Severi et al., 2007) | Case–control study | Australia | Caucasian | rs1447295 | 821/732 |
| Dominika Wokołorczyk, 2008 (Wokolorczyk et al., 2008) | Case–control study | Poland | Caucasian | rs6983267 | 1910/1885 |
| S. Lilly Zheng, 2007 (Zheng et al., 2007) | Case–control study | USA | Caucasian | rs16901979 | 1563/576 |
| rs1447295 | |||||
| rs6983267 | |||||
| rs4242382 | |||||
| rs7017300 | |||||
| rs7837688 | |||||
| rs4645959 | |||||
| rs10086908 | |||||
| Jae Y. Joung, 2012 (Joung et al., 2012) | Hospital-based case–control study | Korea | Asian | rs16901979 | 194/169 |
| rs1447295 | |||||
| rs6983267 | |||||
| Naoki Terada, 2008 (Terada et al., 2008) | Case–control study | Japanese | Asian | rs1447295 | 507/387 |
| rs6983267 | |||||
| Michael N. Okobia, 2011 (Okobia et al., 2011) | Case–control study | Caribbean | African | rs16901979 | 338/426 |
| rs1447295 | 354/438 | ||||
| rs6983267 | 343/426 | ||||
| Claudia A. Salinas, 2008 (Salinas et al., 2008) | Population-based case–control study | USA | Caucasian | rs1447295 | 1252/1233 |
| rs6983561 | 1264/1236 | ||||
| rs10090154 | 1288/1250 | ||||
| rs7000448 | 1262/1239 | ||||
| rs6983267 | 1258/1238 | ||||
| rs13254738 | 1256/1234 | ||||
| rs7837688 | 1260/1241 | ||||
| rs4645959 | 1261/1238 | ||||
| rs1016343 | 1253/1233 | ||||
| rs7837328 | 1258/1239 | ||||
| rs16901966 | 1302/1260 | ||||
| rs10505476 | 1256/1233 | ||||
| rs7837328 | 1258/1239 | ||||
| rs13281615 | 1254/1234 | ||||
| Marnita L Benford, 2010 (Benford et al., 2010) | Case–control study | USA | Caucasian | rs16901979 | 192/512 |
| rs1447295 | 189/523 | ||||
| rs6983561 | 186/908 | ||||
| rs10090154 | 189/505 | ||||
| rs4242382 | 193/1167 | ||||
| rs4242384 | 193/524 | ||||
| Siqun Lilly Zheng, 2010 (Zheng et al., 2010) | Population-based case–control study | China | Asian | rs16901979 | 283/145 |
| rs1447295 | 284/151 | ||||
| rs6983267 | 282/152 | ||||
| Rosalind A Eeles, 2007 (Eeles et al., 2008) | Population-based case–control study | United Kingdom | Caucasian | rs1447295 | 1906/1934 |
| rs6983267 | |||||
| rs4242382 | |||||
| rs7017300 | |||||
| rs7837688 | |||||
| rs1016343 | |||||
| rs7837328 | |||||
| rs4242384 | |||||
| rs620861 | |||||
| rs16901966 | |||||
| rs7837328 | |||||
| Jielin Sun, 2008 (Sun et al., 2008) | Population-based case–control study | USA | Caucasian | rs16901979 | 1625/560 |
| rs1447295 | |||||
| rs6983561 | |||||
| rs10090154 | |||||
| rs7000448 | |||||
| rs6983267 | |||||
| rs13254738 | |||||
| rs4242382 | |||||
| rs7017300 | |||||
| rs7837688 | |||||
| rs10086908 | |||||
| Amalia Papanikolopoulou, 2011 (Papanikolopoulou et al., 2011) | Case–control study | Greece | Caucasian | rs6983267 | 86/99 |
| Kathryn L. Penney, 2009 (Penney et al., 2009) | Case–control study | USA | Caucasian | rs6983267 | 1305/1402 |
| rs13254738 | |||||
| Liang Wang, 2007 (Wang et al., 2007) | Case–control study | USA | Caucasian | rs1447295 | 1121/545 |
| DG8S737 | |||||
| S. Lilly Zheng, 2008 (Zheng et al., 2008) | Population-based case–control study | Sweden | Caucasian | rs16901979 | 2893/1781 |
| rs1447295 | |||||
| rs6983561 | |||||
| rs10090154 | |||||
| rs7000448 | |||||
| rs6983267 | |||||
| rs4242382 | |||||
| rs7017300 | |||||
| rs7837688 | |||||
| Ying-Cai Tan, 2008 (Tan et al., 2008) | Case–control study | India | Asian | rs16901979 | 153/227 |
| rs1447295 | |||||
| rs6983267 | |||||
| Viorel Jinga, 2016 (Jinga et al., 2016) | Case–control study | Romania | Caucasian | rs16901979 | 955/1007 |
| Cheryl D. Cropp, 2014 (Cropp et al., 2014) | Population-based case–control study | USA | Caucasian | rs7008482 | 522/510 |
| Lin-Lin Zhang, 2014 (Zhang et al., 2014) | Case–control study | China | Asian | rs7837328 | 388/384 |
| rs4242384 | |||||
| Ignacio F. San Francisco, 2014 (San Francisco et al., 2014) | Case–control study | Chile | Hispanic | rs1447295 | 83/21 |
| rs6983267 | |||||
| rs7837328 | |||||
| rs620861 | |||||
| Adam B. Murphy, 2012 (Murphy et al., 2012) | Case–control study | Cameroon | African | rs16901979 | 308/469 |
| rs1447295 | |||||
| rs6983561 | |||||
| rs7000448 | |||||
| rs6983267 | |||||
| rs7008482 | |||||
| Fang Liu, 2011 (Liu et al., 2011) | Case–control study | China | Asian | rs16901979 | 1108/1525 |
| rs1447295 | |||||
| rs6983267 | |||||
| rs620861 | |||||
| rs10086908 | |||||
| Ethan M. Lange, 2012 (Lange et al., 2012) | Case–control study | USA | Caucasian | rs1447295 | 1176/1101 |
| rs6983267 | |||||
| Bao-Li Chang, 2011 (Chang et al., 2011) | Case–control study | USA | African | rs16901979 | 2642/2584 |
| rs1447295 | 3167/3325 | ||||
| rs6983561 | 2764/3255 | ||||
| rs10090154 | 1683/1403 | ||||
| rs7000448 | 1698/2329 | ||||
| rs6983267 | 3666/2992 | ||||
| rs13254738 | 2557/2277 | ||||
| rs4242382 | 1289/1527 | ||||
| rs7837688 | 636/330 | ||||
| rs1016343 | 1975/1830 | ||||
| rs7008482 | 2172/1760 | ||||
| rs7837328 | 473/772 | ||||
| rs10086908 | 861/876 | ||||
| rs16901966 | 861/875 | ||||
| rs10505476 | 473/744 | ||||
| rs7837328 | 473/772 | ||||
| Yunfei Wang, 2011 (Wang et al., 2011) | Case–control study | USA | African | rs16901979 | 127/345 |
| rs1447295 | |||||
| rs6983561 | |||||
| rs10090154 | |||||
| rs7000448 | |||||
| rs6983267 | |||||
| rs4242382 | |||||
| Tatsuya Hamano, 2010 (Hamano et al., 2010) | Case–control study | Japan | Asian | rs1447295 | 158/119 |
| DG8S737 | |||||
| Dominika Wokołorczyk, 2010 (Wokolorczyk et al., 2010) | Hospital-based case–control study | Poland | Caucasian | rs1447295 | 690/602 |
| DG8S737 | |||||
| Meredith Yeager, 2009 (Yeager et al., 2009) | Case–control study | USA | Caucasian | rs620861 | 10286/9135 |
| rs13281615 | |||||
| Ali Amin Al Olama, 2009 (Al Olama et al., 2009) | Case–control study | United Kingdom | Caucasian | rs6983561 | 1906/1934 |
| rs10090154 | |||||
| rs6983267 | |||||
| rs1016343 | |||||
| rs620861 | |||||
| rs10086908 | |||||
| Miao Liu, 2009 (Liu et al., 2009) | Case–control study | Japan | Asian | rs1447295 | 391/323 |
| rs6983267 | |||||
| Jianfeng Xu, 2009 (Xu et al., 2009) | Case–control study | USA | African | rs16901979 | 868/878 |
| rs1447295 | |||||
| rs6983267 | |||||
| Joke Beuten, 2009 (Beuten et al., 2009) | Cohort Study | USA | Caucasian | rs10505476 | 601/840 |
| hispanic | 196/472 | ||||
| rs7837328 | |||||
| Meredith Yeager, 2007 (Yeager et al., 2007) | Cohort Study | USA | Caucasian | rs1447295 | 4296/4299 |
| rs6983267 | |||||
| rs7837688 | |||||
| Jong Jin Oh, 2017 (Oh et al., 2017) | Hospital-based case–control study | Caucasian | rs1016343 | 1001/2641 | |
| rs7837688 | |||||
| Haitao Chen, 2018 (Chen et al., 2018) | Case–control study | Caucasian | rs6983267 | 779/1643 | |
| rs620861 | |||||
| rs16901979 | |||||
| rs1447295 |