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. 2018 Jul 16;9:760. doi: 10.3389/fphar.2018.00760

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Copyright © 2018 Huang, Hao, Tian, Wen, Zhao, Chen, Lv and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SD-FRE treatment reversed islet hypertrophy in pancreas of KK-Ay mice. (A) Pancreas sections were stained with HE and observed under light microscopy. (B) Pancreas sections were stained with insulin (red), glucagon (green) and DAPI (blue), observed under fluorescence microscopy. Scale bar, 50 μm. Quantified average islet area (C), the percentage of insulin-positive beta cells (D) and glucagon-positive alpha cells (E) in pancreatic islets. Data are mean ± SEM. n = 4 sections per group. ⁺p < 0.05, ⁺⁺⁺p < 0.001 vs. NC group, ^∗∗p < 0.01 vs. DC group.