Fig. 7.

C18:1-Gln exhibits antinociceptive bioactivity in vivo. (A and B) Number of flinches (A) and time spent licking the injected paw (B) after intraplantar administration of capsaicin (1.5 μg per paw). (C) Time spent licking the injected paw after intraplantar administration of 5% formalin (20 µL per paw). (D) Number of abdominal constrictions over 30 min following i.p. injection of 0.6% acetic acid (0.3 mL per mouse). (E) Total number of line crossings during a 5-min open field assay of 8- to 12-wk-old male wild-type mice treated with vehicle or C18:1-Gln (100 mg/kg, i.p.). C18:1-Gln was administered 15 min before the behavioral assays. Data are shown as means ± SEM; **P < 0.01 for the indicated comparison; n = 12 per group.