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. 2018 Jun 14;133(4):497–501. doi: 10.1177/0033354918776641

Table.

Summary of reasons and interpretations for New York City residents reported with a hepatitis C test to the New York City Department of Health and Mental Hygiene between July 1, 2014, and June 30, 2017, identified as treated per the Viral Hepatitis Program treatment algorithm but uncured per the cure algorithm (n = 13 109)a

Reason Uncured No. (%) Interpretation
Anchor test is ≥120 days before June 30, 2017.
 No testing since anchor test. 5573 (42.5) Patient not returning for follow-up/SVR testing
 All tests are within 120 days of anchor test. 3592 (27.4) Patient awaiting SVR test; ceased follow-up testing
Anchor test is <120 days before June 30, 2017. 3055 (23.3) Patient recently started treatment
Most recent RNA test is a high positive (viral load ≥1000 IU/mL).
 Positive test is <1 year after last negative result. 794 (6.1) Treatment relapse; early reinfection
 Positive test is ≥1 year after last negative result. 95 (0.7) Late treatment relapse; late detection of early treatment relapse; reinfection

Abbreviation: SVR, sustained virologic response.

aTreatment algorithm definition: a negative RNA test result in 2014 or later preceded by a high-positive (viral load ≥1000 IU/mL) RNA test result. Cure algorithm definition: a negative RNA test result at least 4 months after an anchor RNA test (the first negative, low-positive [viral load <1000 IU/mL] RNA test after the most recent high-positive RNA test), with no subsequent high-positive RNA test result through June 30, 2017. Data source: New York City Department of Health and Mental Hygiene, Viral Hepatitis Program. Treatment and cure status assessed among 78 886 people diagnosed with hepatitis C and reported to the New York City Department of Health and Mental Hygiene with any hepatitis C test since July 1, 2014.