Table 4.

Expression of activated and regulatory markers as determined by the mean fluorescence intensity (MFI).

Markers	Controls	CM+	CM−	Statistics (Wald)	p-Value
CD3+
CD19	4,894 ± 645	4,439 ± 871	4,128 ± 948	0.47	0.790
CD69	358 ± 33	487 ± 78	423 ± 65	3.01	0.222
CD4+
CD103	384 ± 33a	854 ± 139a,b	568 ± 95b	19.92	<0.0001
CD27	4,024 ± 244a,b	3,088 ± 200a	2,869 ± 286b	12.84	0.002
CD28	3,109 ± 316	2,638 ± 351	2,171 ± 281	4.78	0.091
CD8+
KLRG1	2,638 ± 237	2,964 ± 383	2,897 ± 95	0.95	0.954
NKG2	1,746 ± 334a	3,893 ± 344a,b	1,603 ± 377b	26.9	<0.0001
PD-1	2,667 ± 123	2,876 ± 154	2,956 ± 165	1.67	0.756
CD27	3,965 ± 223a,b	2,978 ± 265a	2,804 ± 290b	13.6	0.001
CD28	2,543 ± 215a,b	1,217 ± 118a	1,489 ± 177b	25.3	<0.0001

Data shown as mean MFI ± SE. Data were analyzed by Generalized Linear Modeling (linear or gamma distribution) adjusted for age and education years.

Statistical significant differences are highlighted in bold font.

^a,bDifferences between groups (Bonferroni post hoc test).