Table 3.

Hazard ratios of recurrent VTE by risk factors

Risk factor	Hazard ratioa	95% CI	Hazard ratioa	95% CI
	Unadjusted		Adjusted
Provoking risk factors (mutually exclusive groups)
Provoked by surgeryc	1.0		1.0
Non‐surgical transient risk factorc	1.8	0.7, 4.8	1.6	0.5, 5.5
Unprovoked VTEc	3.1	1.3, 7.4	4.6	1.7, 11.9
Active cancerc	N/A		N/A
Other risk factors
Male sex	2.0	1.2, 3.3	2.8	1.5, 5.1
Pregnancy	1.1	0.2, 8.1	1.9	0.2, 15.1
Contraceptive use at the time of thrombosis	0.1	0.0, 0.9	0.1	0.0, 0.9
Traveling	1.8	0.9, 3.8	1.5	0.6, 3.8
Immobilization	0.4	0.1, 1.6	0.2	0.0, 1.5
Inflammation	1.9	1.1, 3.4	1.8	0.9, 3.4
Previous VTE	0.7	0.3, 1.3	0.8	0.3, 1.8
Cardiovascular disease	1.3	0.7, 2.2	1.1	0.6, 2.2
Heart failure	1.0	0.1, 7.4	2.0	0.3, 15.2
Known thrombophilia	0.4	0.1, 2.7	0.6	0.1, 4.8
Varicose veins	0.8	0.3, 2.6	1.0	0.3, 3.4
Smoking	0.8	0.4, 1.5	0.7	0.4, 1.5
Family history	0.8	0.5, 1.5	0.9	0.5, 1.7
Risk factors not assessed at baseline
Residual thrombosisd	1.0	0.6, 1.7	1.1	0.6, 2.0
Elevated Villalta scoree , f	1.6	0.9, 3.0	1.6	0.8, 3.5
Elevated D‐dimerb, g	2.5	1.5, 4.3	3.3	1.8, 6.1
High factor VIIIb, g	2.3	1.3, 4.2	2.2	1.2, 4.0
Elevated CRPb, g	1.8	1.0, 3.2	1.5	0.8, 2.7

^aCox proportional hazards model.

^bAdjusted by anticoagulation (time‐varying co‐variable), age, surgery, pregnancy, contraceptive use at the time of thrombosis, travel, inflammation, sex, previous VTE, D‐dimer, and Factor VIII levels.

^cGroups are mutually exclusive, reference is provoked by surgery.

^dAssessed one week before intended cessation of anticoagulation treatment.

^eAssessed at six months.

^f≥5 points.

^gAssessed one month after stop anticoagulation treatment.