Figure 1.

Platelet adhesion/signaling receptors and their ligands. Platelet glycoproteins GPIbα and GPVI can bind a variety of ligands, many of which trigger intracellular signals that lead to platelet activation, degranulation and increased affinity of αIIbβ3 for fibrinogen. Cytoskeletal proteins and 14‐3‐3ζ associate with the cytoplasmic tails of the GPIb‐IX‐V complex. GPIb‐IX‐V contains intersubunit and intrasubunit disulphide bonds, represented by S, symbolising the link between adjacent sulfhydryl moieties in GPIbα and between GPIbα and GPIbβ. Calmodulin (CAM) associates with the juxtamembrane cytoplasmic regions of GPIbβ, GPV, and GPVI. The penultimate residue of GPVI is cysteine, represented by a free sulfhydryl group, SH. Not all cytoplasmic components known to associate with cytoplasmic tails of each receptor are shown