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. Author manuscript; available in PMC: 2019 Jun 13.
Published in final edited form as: Cell Host Microbe. 2018 Jun 13;23(6):775–785.e5. doi: 10.1016/j.chom.2018.05.004

Figure 2.

Figure 2

Tryptamine evoked ΔIsc is blocked by 5-HT4R antagonist irrespective of sex and microbial colonization. ΔIsc in response to tryptamine applied apically (3mM, paired t-test) and cumulative concentrations of tryptamine applied basolaterally (two-way ANOVA) respectively either alone or in the presence of 5-HT4R antagonist, GR-113808 (30nM) in GF male (A, B) and GF female mice (C, D). ΔIsc in response to tryptamine applied apically (3mM, paired t-test) and cumulative concentrations of tryptamine applied basolaterally (two-way ANOVA) respectively either alone or in the presence of 5-HT4R antagonist, GR-113808 (30nM) in HM male (E, F) and HM female mice (G, H). ΔIsc in response to tryptamine applied apically (3mM, paired t-test) and cumulative concentrations of tryptamine applied basolaterally (two-way ANOVA) respectively either alone or in the presence of 5-HT4R antagonist, GR-113808 (30nM) in CR male (I, J) and CR female mice (K, L). n=5–6, *P < 0.05.