Table 4.

Antiparasitic Therapy for Entamoeba histolytica Infection

	Drug of Choice	Daily Dose	Duration, d	Alternatives
Tissue-active agent
Amebic colitisa	Metronidazole or	750 mg po TID (35–50 mg/ kg/d divided TID)	5–10	Nitazoxanideb
	Tinidazole	2 g po once daily (50 mg/kg once daily)	3–5
Amebic liver abscess and disseminated amebic diseasea	Metronidazole or	750 mg po TID (35–50 mg/ kg/d divided TID)	10	-
	Tinidazole	2 g po once daily (50 mg/kg once daily)	5
Luminal agent
Asymptomatic carriage or following tissue-active agent	Paromomycin	25–35 mg/kg/d by mouth divided TID	7	Iodoquinol/diiodohydroxyquin diloxanide furoatec

Abbreviations: BID, twice daily; IV, intravenous; po, by mouth; TID, three times daily.

^aSevere disease or unable to tolerate oral therapy, use metronidazole 1500 mg IV divided TID (7.5–30 mg/kg/d divided TID) [46].

^bLimited data, 500 mg po BID (≥12 years), 200 mg BID (age 4–11 years), or 100 mg BID (age 1–3 years) for 3 days.

^cIodoquinol 650 mg po TID (30–40 mg/kg/d po divided TID for children) for 20 days after meals (optic neuritis and peripheral neuropathy have been reported), diloxanide furoate 500 mg po TID (20 mg/kg/d po divided TID for children) for 10 days [57].