Table 3.
Comparison Among IL-1Ra Tertiles
| Variable | Tertile | P Value a | ||
|---|---|---|---|---|
| Lowest (<195.0 pg/mL; n = 64) | Middle (195.1–286.0 pg/mL; n = 64) | Highest (>286.0 pg/mL; n = 63) | ||
| Serum hs-CRP, mg/L | ||||
| Mean | 0.19 | 0.33 | 1.45 | <0.001 |
| Median | 0.09 | 0.09 | 0.70 | <0.001b |
| Range | 0.09–2.13 | 0.09–5.52 | 0.09-9.43; n = 59 | |
| Serum insulin, mU/L | 9.0 (8.0–10.0) | 9.8 (8.9–10.6) | 11.8 (10.5–13.0) | <0.001 |
| Blood glucose, mmol/L | 4.3 (4.2–4.4) | 4.3 (4.3–4.4) | 4.4 (4.3–4.4) | 0.969 |
| QUICKI | 0.358 (0.352–0.364) | 0.352 (0.346–0.357) | 0.343 (0.337–0.349) | 0.001 |
| 0.046b | ||||
| Serum IGFBP-1, μg/L | 74.7 (65.1–84.2) | 67.0 (59.9–74.1) | 56.6 (46.6–66.5) | 0.001 |
| 0.030b | ||||
| Serum SHBG, nmol/L | 85.2 (77.0–93.4) | 79.0 (71.7–86.3) | 56.3 (49.0–63.7) | <0.001 |
| <0.001b | ||||
| Serum leptin, μg/L | ||||
| Mean | 9.4 | 10.7 | 25.3 | <0.001 |
| Median | 4.4 | 8.3 | 23.0 | <0.001b |
| Range | 0.3–52.4 | 0.9–41.0 | 0.8–101.5 | |
| Serum adiponectin, mg/L | 10.9 (9.4–12.3) | 11.7 (9.9–13.4) | 10.4 (9.1–11.7) | 0.700 |
| Serum triglycerides, mmol/L | 0.81 (0.73–0.88) | 0.95 (0.84–1.07) | 0.99 (0.88–1.11) | 0.037 |
| Serum HDL cholesterol, mmol/L | 1.40 (1.33–1.47) | 1.31 (1.24–1.38) | 1.26 (1.20–1.32) | 0.016 |
| Serum apoB, g/L | 0.69 (0.64–0.74); n = 63 | 0.74 (0.69–0.78) | 0.72 (0.67–0.76); n = 62 | 0.170 |
| BMIadj, kg/m2 | 19.5 (18.9–20.1) | 20.5 (19.8–21.3) | 24.3 (23.3–25.4) | <0.001 |
| <0.001b | ||||
| WHtR | 0.41 (0.40–0.41) | 0.42 (0.41–0.43) | 0.47 (0.45–0.49) | <0.001 |
| <0.001b | ||||
| 24h-systolic BP, mm Hg | 116 (114–118); n = 60 | 117 (114–119); n = 61 | 118 (116–120); n = 58 | 0.449c |
| 24-h diastolic BP, mm Hg | 68 (66–69); n = 60 | 69 (68–70); n = 61 | 69 (68–70); n = 58 | 0.244c |
| Sex, F/M, no. | 36/28 | 42/22 | 31/32 | 0.172d |
| Pubertal development,e early or late stage, no. | 39/25 | 31/33 | 36/27 | 0.345d |
| Tanner B/G stage | 0.652d | |||
| 1 | 11 (4/7) | 12 (7/5) | 17 (3/14) | |
| 2 | 28 (10/18) | 19 (9/10) | 19 (5/14) | |
| 3 | 14 (12/2) | 21(15/6) | 15 (11/4) | |
| 4 | 9 (8/1) | 9 (8/1) | 9 (9/0) | |
| 5 | 2 (2/0) | 3 (3/0) | 3 (3/0) | |
Data given as mean (95% CI); medians and ranges are given for the variables with skew distributions.
Abbreviation: B/G, breast/genital development.
a
Independent-samples Kruskal-Wallis test, Bonferroni-adjusted P value, comparison between the lowest and the highest IL-1Ra tertile.
b
Independent-samples Kruskal-Wallis test for the differences, Bonferroni-adjusted P value, comparison between the middle and the highest IL-1Ra tertile.
c
Analysis of covariance adjusted for BMIadj and height (SDS).
d
χ 2 test.
e
Early stage of puberty: breast or genital scores 1–2; late stage of puberty: breast or genital scores 3–5.