Table 2.
Association of ADHD PRS with sex of individuals with anxiety or depression diagnoses
| Definition | Diagnosis | All diagnosed individuals | Excluding children with comorbid ADHD diagnosis | ||||
|---|---|---|---|---|---|---|---|
| Males/Females | OR (CI) | p | Males/Females | OR (CI) | p | ||
| Registry‐based clinical diagnoses (CATSS) | Anxiety | 107/158 | 1.42 (1.09–1.86) | .01 | 73/136 | 1.75 (1.26–2.44) | .00087 |
| Depression | 79/138 | 1.35 (0.98–1.85) | .062 | 59/119 | 1.68 (1.15–2.47) | .0074 | |
| Anxiety/depression | 154/234 | 1.39 (1.12–1.73) | .0031 | 111/202 | 1.66 (1.28–2.16) | .00013 | |
| Screening‐based research diagnoses (CATSS) | Anxiety | 65/231 | 1.08 (0.83–1.40) | .58 | 59/218 | 1.08 (0.82–1.41) | .60 |
| Depression | 89/223 | 1.15 (0.88–1.50) | .32 | 77/209 | 1.15 (0.86–1.53) | .34 | |
| Anxiety/depression | 119/351 | 1.15 (0.94–1.42) | .18 | 107/334 | 1.15 (0.92–1.42) | .21 | |
| Algorithm‐based research diagnoses (ALSPAC) | Anxiety | 178/305 | 1.07 (0.89–1.29) | .48 | 67/138 | 1.00 (0.75–1.35) | .99 |
| Depression | 98/254 | 1.08 (0.87–1.36) | .48 | 46/121 | 1.08 (0.79–1.49) | .62 | |
| Anxiety/depression | 249/475 | 1.04 (0.89–1.21) | .65 | 101/221 | 1.02 (0.81–1.28) | .88 | |
CI: 95% confidence interval. Males are the reference sex, coded as ‘0’ and females are coded as ‘1’. Odds ratios refer to association of ADHD PRS with being a female. ADHD, Attention deficit hyperactivity disorder; ALSPAC, Avon Longitudinal Study of Parents and Children; CATSS, Child and Adolescent Twin Study in Sweden; PRS, polygenic risk scores.