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. 2018 Mar 7;74(8):1751–1758. doi: 10.1002/ps.4870

Figure 1.

PS-4870-FIG-0001-c

Parallel RNA silencing pathways in the plant cytoplasm, insect cytoplasm and plant chloroplast. In the plant cytoplasm, delivered dsRNA or hpRNA is processed by Dicer enzymes into primary siRNAs, which in turn direct AGO1 to their target mRNAs. Silencing amplification producing secondary siRNAs is then driven by RdRps. This amplification mechanism is absent in insect cells because of the lack of RdRps. In plant chloroplasts, as there is no Ago and DCL activity, dsRNA delivered into this compartment are not processed.