Table 1.

Associations between pharmacokinetic parameters and albuminuria and bodyweight response at 2 weeks

	Mean (95% CI) % change in UACR per 2‐fold increase in atrasentan concentration	P	Mean (95% CI) change in bodyweight in kg per 2‐fold increase in atrasentan concentration	P
Ctrough	−9.8 (−15.7 to −3.5)	.003	0.31 (0.10‐0.52)	.004
Css	−10.2 (−16.3 to −3.6)	.003	0.30 (0.08‐0.52)	.008
Cmax	−10.3 (−16.6 to −3.5)	.004	0.28 (0.05‐0.51)	.019
24‐hour AUCd14	−9.9 (−16.1 to −3.3)	.004	0.30 (0.08‐0.52)	.008