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. 2009 Jul 23;114(14):3074–3083. doi: 10.1182/blood-2008-11-188698

Figure 4.

Figure 4

Effect of aPL Abs on thrombus formation in A2−/− mice. A2−/− or A2+/+ mice were treated with either IgG-APS, IgG-NHS (A), 4C5, anti-A2 MoAb, or MuMoAbC as control (B), as indicated in “Analysis of thrombus dynamics.” Thrombi were induced in the animals, and thrombus size was measured in square microns (μm2). The data are expressed as means ± SD (5-10 animals were used per group). ¶Statistically different from A2+/+ mice treated with IgG-NHS (A; P = .001) or MuMoAbC (B; P = .002). *Statistically different from A2+/+ mice treated with IgG-APS (A; P = .002) or 4C5 (B; P = .005). **Statistically different from A2−/− mice treated with IgG-APS (A; P = .001) or 4C5 (B; P = .009).