Figure 4.

Level of p21 transcript in patient cells expressing wild‐type or mutant RPS19. The increased level of p21 typical of DBA patient cells is corrected by the expression of a wild‐type RPS19 transgene but not by the expression of RPS19 carrying a pathogenic mutation. Results obtained by quantitative RT‐PCR performed on P1 and P2 patient cells were considered biological replicates. Asterisks represent statistically significant differences between samples with wild‐type and mutant exogenous RPS19: *P < 0.05; **P < 0.01. Error bars represent standard error of the mean