Table 3.
Diagnostic efficacy of MRI and 18F-FDG PET/CT in finding the malignancy in patients with solitary VCF
| Feature | Group
|
Specificity (%) | PPV | NPV | |
|---|---|---|---|---|---|
| Malignant fracture | Benign fracture | ||||
| Epidural mass formation | 25/33 | 6/24 | 75.0 | 80.6 | 69.2 |
| Convex posterior cortex | 21/33 | 5/24 | 79.1 | 80.7 | 61.2 |
| Pedicle enhancement | 23/27 | 6/20 | 70.0 | 79.3 | 77.8 |
| All three features | 14/27 | 2/20 | 90.0 | 87.5 | 58.0 |
| 18F-FDG PET/CT | 33/33 | 6/10 | 40.0 | 84.7 | 100.0 |
Notes: Values represent number of lesions showing the specified feature/number of lesions evaluated. Group assignment was based on final diagnosis as determined by biopsy or clinical follow-up.
Abbreviations: VCF, vertebral compressed fracture; PPV, positive predictive value; NPV, negative predictive value; 18F-FDG, 2-[fluorine-18]-fluoro-2-deoxy-D-glucose; PET, positron emission tomography; CT, computed tomography.