Table 2.

DLQI regression results

Angioedema Classification	Within Group			Contrast in LS Mean
	n	LS Mean	SE	Comparison	LS Mean	SE	95% CI	P value
Primary analysis: ANCOVA for DLQI total score by angioedema classification (assigning Misaligned category to Yes‐angioedema category)
No‐angioedema	150	7.27	0.850	vs Yes	−2.61	0.558	−3.71 to −1.51	<.0001
Yes‐angioedema	399	9.88	0.722
Sensitivity analysis: ANCOVA for DLQI total score by angioedema classification (removing the Misaligned category)
No‐angioedema	150	6.73	0.902	vs Yes	−2.96	0.586	−4.12 to −1.81	<.0001
Yes‐angioedema	232	9.69	0.795

LS means, 95% CIs and P values are from an ANCOVA model with covariates: angioedema classification, UAS7_TD score (continuous), age at enrolment (continuous), sex (male and female), country (Canada, France, Germany, Italy, Spain, the Netherlands and the UK), disease duration from diagnosis to enrolment (continuous) and comorbidities at enrolment (hypersensitivity to NSAIDs [yes/no], Hashimoto's [yes/no] and asthma [yes/no]). ANCOVA, analysis of covariance; CI, confidence interval; DLQI, Dermatology Life Quality Index; LS, least squares; n, number of subjects with data for all model inputs; NSAIDs, nonsteroidal anti‐inflammatory drugs; SE, standard error; UAS7_TD, Urticaria Activity Score over 7 days, twice‐daily assessment.