Box 1.

Data/parameter requirements, preferred sources, and possible alternatives for computation of the burden of adverse events following immunization using the DALY

Data/Parameter	Preferred Source	Alternative(s)
Vaccination‐attributable event incidence rate	Electronic health record database (EHR) linked to vaccination register	Systematic review of published relative risk estimates, applied to background incidence rates (from EHR or from systematic review of appropriate studies)
Outcome tree/subsequent sequelae, with associated risks	Published studies describing outcomes and quantified recurrence and/or progression risks	Clinical knowledge of appropriate medical experts
Disability weight	Disability weight database; weights elicited using standard methods	Proxy health outcome selected by medical experts and weights for proxies adopted or elicit new weights using established methods
Disability duration	Systematic review of studies reporting duration of health outcome	Clinical knowledge of appropriate medical experts