Table 1.
The stability of 89Zr-3 and 89Zr-DFO was tested against transchelation in the presence of an excess of competitor chelator over seven days (pH 7). The controls (complexes in solution without competitor) show high stability (>99% intact complex) (A). The stability of the 89Zr-complexes was also tested in mouse serum over seven days (B).
| Fraction of intact complex (% ± SD) |
||||||||
|---|---|---|---|---|---|---|---|---|
| Complex | Competitor | 0 min | 1 h | 3 h | 1 d | 3 d | 7 d | |
| A | 89Zr-3 | EDTA | >99 | >99 | >99 | >99 | >99 | >99 |
| DFO | >99 | >99 | >99 | >99 | >99 | >99 | ||
| 89Zr-DFO | EDTA | >99 | >99 | >99 | 75.63±3.07 | 63.1±0.75 | 65.5±4.42 | |
| 3 | >99 | 35.8±9.8 | 4.1±2.35 | 0 | 0 | 0 | ||
| B | 89Zr-3 | Mouse Serum | >99 | -- | >99 | >99 | >99 | >99 |
| 89Zr-DFO | Mouse Serum | >99 | -- | >99 | 97.7±0.53 | 94.7±0.78 | 90.6±1.75 | |